GENTAMICIN Inj (4mg /ml )
Gentamicin has a mechanism of action and spectrum of activity (primarily gram-negative aerobes) similar to the other aminoglycosides. Like the other aminoglycoside antibiotics, it acts on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibiting protein synthesis. It is considered a bactericidal concentration-dependent antibiotic.
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DOGS:
For susceptible infections:
a) For empiric therapy: 10–14 mg/kg once a day (route not specified; assume IV, SC, IM—Plumb) (Autran de Morais 2009)
b) For localized, urinary infections: First dose of 4.4 mg/kg IM, SC and then 2.2 mg/kg IM, SC once daily (q24h) for 7–10 days;
For orthopedic and soft tissue infections: 4.4–6.6 mg/kg IV, IM, SC once daily (q24h) for <7 days.
For bacteremia, sepsis: 6.6 mg/kg IV, IM, SC once daily (q24h) for <7 days.
CATTLE:
4 mg/kg body weight