Trimethoprim is available as a single antibiotic or in combination with sulfamethoxazole (a sulfonamide antibiotic). The antibiotics act synergistically to block sequential steps in bacterial folate metabolism:
- Trimethoprim (TMP) prevents reduction of dihydrofolate to tetrahydrofolate.
- Sulfamethoxazole (SMX) inhibits conversion of p-aminobenzoic acid to dihydropteroate.
This synergy results in maximal antibacterial activity, which is often bactericidal.
Trimethoprim/sulfamethoxazole (TMP/SMX) is available as a fixed combination consisting of a 1:5 ratio
Non-returnable
₹38.00 ₹65.00
